AMSI grant recipient profile: Claire Cheng

I am a first-year PhD student at the School of Chemistry and Molecular Biosciences, University of Queensland. My research focuses on tracing cell development using multi-omics data through bioinformatics methods. Specifically, I aim to develop techniques for sorting cells by their state and predicting cell fates based on trajectory analysis. During my undergraduate studies, I worked closely with cancer sample donors and gained a deep appreciation for the importance of identifying cancer cells with metastatic potential. This experience inspired my goal to contribute to improving cancer metastasis diagnosis, ultimately helping to save lives.

Outside of my work as a bioinformatician, I am the proud mother of a two-year-old daughter who adores Bluey. My free time is dedicated to exploring, playing, and growing alongside her in the Sunshine State, cherishing the small moments that shape our journey together.

Can you describe the area of mathematics or bioinformatics you’re focusing on, and what you hope to achieve through your research?

I’m focusing on developing computational methods in bioinformatics to understand how cells change and develop over time. By analysing multi-omics data, which includes various biological data types like scRNA and scATAC, I aim to create tools that can sort cells by their states and predict their future roles or behaviours. My goal is to apply this knowledge to areas like cancer research, helping identify cells that might cause metastasis and improving early diagnosis and treatment options. 

What inspired you to pursue a career in bioinformatics or the mathematical sciences?

My love for mathematics began when I was a little girl, inspired by my grandmother, who was a primary school math teacher. During summer holidays, I would sit beside her, solving problems from a mathematics problem solving book. She introduced me to clever tricks and fostered my curiosity, making those summers full of joy.

As I continued my studies, I participated in various math competitions during high school, which deepened my passion and honed my skills. Mathematics has always been more than just a subject I love—it’s a connection to cherished memories with my grandmother and a source of fascination driving my academic journey.

If you could give advice to your younger self, what would it be?

I would advise my younger self to focus on understanding the fundamental systems and concepts of mathematics more deeply, rather than just solving tricky or competitive problems. While problem-solving is important, investing time in grasping mathematical theories and concepts provides a stronger foundation for creativity and innovation. It’s through this deeper understanding that one can develop meaningful models and apply mathematics to solve real-world challenges.

How was your AMSI BioInfoSummer experience?

Attending AMSI BioInfoSummer was a truly enriching experience. The conference offered a fantastic opportunity to learn about the latest trends in bioinformatics technologies and gain insights into cutting-edge research through the talks. For my own research, which involves processing scRNA-seq data, the sessions this year were highly relevant and informative. I was particularly inspired by a presentation on spatial-transcriptomics, where a researcher from the US demonstrated an innovative approach combining mathematical models with machine learning to utilize spatial information for cancer studies.

In addition to the academic content, I had the chance to connect with peers working in the same field, exchange ideas, and learn about their projects. The career discussion session was especially valuable, providing insights into diverse career paths available in bioinformatics.

I would highly recommend BioInfoSummer to students from both biology and mathematics backgrounds. The conference serves as a bridge between these disciplines and offers an excellent platform for networking, learning, and exploring new career opportunities in bioinformatics.

You received an AMSI BioInfoSummer travel grant to attend in person. How did this grant impact your ability to participate fully?

Yes, the AMSI BioInfoSummer travel grant had a significant impact on my ability to fully participate in the workshop. Without the grant, I might have considered skipping the first session, as it wasn’t directly related to my research topic. However, attending that session turned out to be incredibly insightful. It offered a unique perspective on understanding cells through mathematical modelling, which broadened my understanding and inspired new ways of thinking about my own research. The grant ensured that I could attend every session and maximize the learning and networking opportunities throughout the event.

What was the most valuable experience or takeaway from AMSI BioInfoSummer?

There were many aspects of AMSI BioInfoSummer that I thoroughly enjoyed, including the engaging talks, the career development session, and even the delicious food. What I appreciated most, however, was the opportunity to hear from international speakers. They provided a unique chance to understand the advancements and cutting-edge work happening in bioinformatics outside of Australia. Listening to experts from renowned overseas institutes offered insights that are far more impactful than simply reading papers in the office. It was an inspiring and enriching experience.

 Where do you see your journey in mathematical sciences taking you in the next 5–10 years?

Yes, AMSI BioInfoSummer introduced me to new career pathways and ideas for my future. I had the chance to meet researchers involved in clinical studies, which inspired me to consider applying AI to clinical diagnostics after graduation. Fields such as AI-driven drug design or therapy selection are particularly appealing to me, and I see them as potential career options in the next 5–10 years. This experience has broadened my perspective and reinforced my interest in using mathematical and computational tools to make tangible contributions to healthcare and medicine.

Is there anything else you’d like to share about your experience or feedback on AMSI BioInfoSummer or the travel grant?

I really appreciated the inclusion of international presenters, as they provided valuable insights into global research trends beyond Australia. The career development session was particularly impactful for students like me. Hearing from senior professionals about potential career paths was both inspiring and encouraging, motivating me to consider continuing my academic journey. If I could suggest an improvement, it would be to make the workshop sessions more in-depth, allowing participants to fully immerse themselves in the topics. Overall, it was an incredible experience, and I’m grateful for the opportunity to participate.