Shivangi Shukla
University of Western Australia
I am currently international first year PhD student at the University of Western Australia. I hold a master’s degree in biotechnology from Jamia Millia Islamia, New Delhi, India, and a bachelor’s degree in biomedical science from the University of Delhi, India. My PhD research project will involve the high-resolution analysis of the cross-reactive immune responses to pathogens such as influenza and SARS-CoV-2 and how this information can inform future strategies to improve vaccine design.
Can you describe the area of mathematics or bioinformatics you’re focusing on, and what you hope to achieve through your research?
I am working on a fascinating PhD project at the intersection of Viral Immunology, bioinformatics, and computation biology. My focus is on generating and analysing large biological datasets, such as transcriptomes (gene expression data) and protein profiles from single cells, offering insights into complex immune responses. A major goal is to explore how our immune system reacts to viral infections and vaccines, specifically studying cross-reactivity—how immunity to one virus might affect responses to another. Through mathematical modelling and bioinformatics tools, I aim to contribute to the development of better vaccines, particularly for rapidly evolving RNA viruses, such as influenza or COVID-19.
What inspired you to pursue a career in bioinformatics or the mathematical sciences?
When I first considered this PhD position, I was hesitant to apply due to my lack of prior experience in bioinformatics/ computation biology. However, with the continuous support and encouragement of my supervisor, I was motivated to design a project focused on analysing large datasets. This process not only built my confidence but also deepened my passion for this area of research.
If you could give advice to your younger self, what would it be?
Mathematical sciences and bioinformatics may seem daunting at first, especially for someone like me with a background primarily in molecular biology and wet lab experience. However, persistence and curiosity are your greatest allies. Don’t hesitate to broaden your horizons and embrace opportunities to expand your learning curve, you will be surprised at what you can achieve.
How was your AMSI BioInfoSummer experience?
I have a keen and growing interest in bioinformatics and computational science and am always seeking opportunities to advance my skills in this area. Attending AMSI BioInfoSummer was a great way to elevate my computational abilities and gain exposure to cutting-edge developments in the field. The program offered a perfect blend of technical workshops, engaging talks, and networking opportunities with experts and peers. I would highly recommend AMSI BioInfoSummer to my peers. The program is incredibly diverse, covering a wide range of topics and skill levels, making it accessible and enriching for everyone, whether you’re just starting out or looking to deepen your expertise.
You received an AMSI BioInfoSummer travel grant to attend in person. How did this grant impact your ability to participate fully?
Receiving an AMSI travel grant to attend the conference was an invaluable experience, especially coming all the way from Western Australia. The conference provided exposure to cutting-edge topics such as whole-cell modelling, machine learning and AI applications in genomics, as well as emerging technologies and tools shaping the field. I gained deeper understanding of link between Biology and data science, and high throughput sequencing data analysis along with networking with esteemed researcher in this field and an opportunity for future collaboration.
What was the most valuable experience or takeaway from AMSI BioInfoSummer?
My main takeaway from AMSI BioInfoSummer was the opportunity to gain insights into cutting-edge advancements in computation biology and its applications in genomics. I particularly liked the public lecture on Preparing for the age of genomic medicine on day 1 and careers & industry networking session on day2 and it was equally valuable as it provided an opportunity to ask questions with like-minded researchers and industry professionals from diverse background. Networking with them opened doors to potential collaborations and exposed me to new career pathways I had not considered before.
Where do you see your journey in mathematical sciences taking you in the next 5–10 years?
The most valuable part of the AMSI bioinfo summer program was gaining exposure in the combination of biology and mathematical sciences that both participants and lecturers were working on. Hearing about their fields of research and the journeys that led them there was an enriching experience -one that I will certainly carry with me in my PhD journey.
In future, I see myself working in interdisciplinary science leading to impactful contributions in the field of bioinformatics and immunogenetics. I aim to develop advanced computational models and bioinformatics tools to tackle pressing challenges in vaccine development, infectious disease, and cancer Immunotherapy research. My long-term goal includes working at the interface of academia and industry.
Is there anything else you’d like to share about your experience or feedback on AMSI BioInfoSummer or the travel grant?
I would like to thank to organizer and funding for travel grant making this incredible experience possible that exceeded my expectations. AMSI BioInfoSummer has left me inspired and better equipped to tackle the challenges in my research journey.