Marnie Petrucci
Curtin University
My background is in Metallurgy, Chemistry, and Molecular Genetics. After working as a Metallurgist and raising three children, I returned to study and earned a BSc in Molecular Genetics and Biotechnology, followed by an Honours degree in Biomedical Science. I’m now pursuing a PhD in Mathematics and Statistics, focusing on using statistical methods to explore the links between genetics and white matter lesions in the brain.
My research looks at how genetic variation affects the development and progression of these lesions, which are associated with various neurological and cognitive conditions. By combining genetics, neuroimaging, and statistical analysis, I’m working to identify patterns and associations that can give us better insights into the biological mechanisms behind white matter pathology.
My interdisciplinary background gives me a unique perspective, blending genetics, chemistry, and statistical modelling to tackle these questions in innovative, data-driven ways. This combination allows me to approach complex research problems from multiple angles and contribute meaningfully to our understanding of brain health.
Can you describe the area of mathematics or bioinformatics you’re focusing on and what you hope to achieve through your research?
My research combines genetics, neuroimaging, and statistical analysis to explore differences between two types of brain changes—periventricular white matter hyperintensities (PVWMHs) and deep white matter hyperintensities (DWMHs)—linked to health issues like stroke, dementia, and depression. Using genetic and brain scan data from the UK Biobank, I aim to identify unique genetic markers associated with each type, uncover how risk factors like high blood pressure contribute, and understand their role in health conditions. This research could lead to better prevention and treatment strategies for memory loss, depression, and dementia.
What inspired you to pursue a career in bioinformatics or the mathematical sciences?
I have always been interested in statistics, having completed several courses throughout my early career. However, an introductory Bioinformatics unit in the final year of my undergraduate degree truly inspired me. The unit was taught by a fantastic lecturer (now my PhD co-supervisor), and their passion and guidance deepened my interest in the field. I realised that my love of computers, statistics, and genetics could be combined into a career that excites me. This lecturer introduced me to my current PhD supervisor, ultimately leading me to pursue my research project.
If you could give advice to your younger self, what would it be?
I would tell my younger self to stay curious and keep learning, even when things get tough. Mistakes are okay—they’re just part of the learning process. I’d also say to build good relationships with mentors and peers because they can offer guidance and open up opportunities. Most importantly, trust that combining your interests—for me, statistics, computers, or biology—can lead to an exciting and fulfilling career.
How was your AMSI BioInfoSummer experience?
I had a great experience at AMSI BioInfoSummer! I attended to learn more about bioinformatics, connect with others in the field, and gain practical skills. The workshops and talks were insightful and great for meeting peers and experts. If a peer asked me if they should go, I’d say it’s a fantastic opportunity to learn, build connections, and see how math and biology come together to solve real-world problems. I’d recommend it!
You received an AMSI BioInfoSummer travel grant to attend in person. How did this grant impact your ability to participate fully?
The AMSI BioInfoSummer travel grant was a huge help! Without it, attending in person would have been tough because I live further away, and the travel costs were higher. It made it much easier to fully participate in the conference, attend all the workshops, and connect with other students and experts. I’m grateful for the opportunity it gave me!
What was the most valuable experience or takeaway from AMSI BioInfoSummer?
The most valuable part of AMSI BioInfoSummer was connecting with other students and researchers who share similar interests. I gained valuable insights into the practical applications of bioinformatics and various career paths. I met many new colleagues, had engaging discussions, and came away with a few potential ideas that could be applied to my project. Connecting with like-minded individuals made me feel more confident about my future as a bioinformatician.
Where do you see your journey in mathematical sciences taking you in the next 5–10 years?
In the next 5–10 years, I see myself building a career in bioinformatics, focusing on using data analysis and genetics to address important health questions. AMSI BioInfoSummer gave me new insights into career opportunities and reinforced my passion for research and collaboration. I’m excited about working on projects that combine genetics, health, and computational science to make a real impact.
Is there anything else you’d like to share about your experience or feedback on AMSI BioInfoSummer or the travel grant?